| ncRNA name | MEG3 |
| ncRNA Category | lncRNA |
| ID | 55384 |
| Ensembl | ENSG00000214548 |
| Synonyms | GTL2; FP504; prebp1; PRO0518; PRO2160; LINC00023; NCRNA00023; onco-lncRNA-83 |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB samples; RB cell lines WERI-RB1 and Y79 |
| Methods | transfection, qPCR, CCK-8 assay, flow cytometry, Western blot, methylation specific PCR (MSP) |
| Expression pattern | down-regulated |
| Functional description | Hypermethylation of MEG3 promoter was observed more frequently in retinoblastoma tissues and was highly associated with low MEG3 expression and poor survival of retinoblastoma patients. Hypermethylation of MEG3 promoter depressed MEG3 expression, promoted proliferation, inhibited apoptosis and increased β-catenin expression of retinoblastoma cells in vitro. |
| PubMed ID | 29287592 |
| Year | 2017 |
| Title | Hypermethylation of MEG3 promoter correlates with inactivation of MEG3 and poor prognosis in patients with retinoblastoma. |
| Drug-related ncRNA | NO |
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